These are some of my favourite BRIG figures from recent Open Access publications. They are all really amazing and go far beyond what I thought was possible with the tool. I did not make these figures; all credit (and kudos) belong to the respective authors.


“Visualization of the reads selected for each strain mapped onto the S. pyogenes MGAS6180 reference genome. The innermost circles represent the GC content (black), GC skew (purple/green), and rRNA operons of MGAS6180 (pink boxes). BRIG (1) shows the distribution of the number of reads for each individual strain mapped onto the central reference using a window size of 500, arranged from inner to outer colored circles as follows: resequenced reference MGAS6180 (pink), PS001 (yellow), PS006 (orange), PS005 (red), PS007 (maroon), and PS008 (purple). Additional strain-specific regions of difference (RODs) (ϕPS008 and ICESpPS008) are represented as insertions. The outermost circle represents previously reported regions of difference in MGAS6180, namely, prophage elements 6180.1 and 6180.2, prophage remnants 6180.3 and 6180.4, and regions of difference 6180.RD1 and 6180.RD2 (15) (black).”

From Ben Zakour et al. (2012) ‘Analysis of a Streptococcus pyogenes Puerperal Sepsis Cluster by Use of Whole-Genome Sequencing’, J. Clin. Microbiol 50(7). doi: 10.1128/JCM.00675-12


“Distribution of CU fimbrial gene clusters among E. coli pathotypes. The inner ring represents the concatenated nucleotide sequences of the 38 fimbrial operons. Each segment is labelled in the outer ring according to the name and clade [3] of the corresponding fimbrial usher type with the intervening 36 rings displaying the presence of intact CU fimbrial gene clusters in each of the strains analysed. The legend on the right lists the colour of each strain that we included in our study, grouped according to pathogenicity class. Circular comparison was generated using BLAST ring image generator (BRIG) [69]. 1CFT073 contains two copies of the P fimbriae operon.”

From Wurpel et al. (2013) ‘Chaperone-Usher Fimbriae of Escherichia coli.’, PLoS ONE 8(1): e52835. doi:10.1371/journal.pone.0052835


“BlastP comparison of the Janthinobacterium sp. HH01 genome compared against genomes of closely related species. The innermost rings indicate the GC content (black) and GC skew (purple/green). The outer rings represent the genomes of the following microbes in different colorings: Janthinobacterium sp. Marseille, blue; Janthinobacterium sp. PAMC 25724, red; Janthinobacterium sp. GC3, green; and C. violaceum ATCC 12472, black.”

From Hornung et al. (2013) ‘The Janthinobacterium sp. HH01 Genome Encodes a Homologue of the V. cholerae CqsA and L. pneumophila LqsA Autoinducer Synthases’, PLoS ONE 8(2): e55045.