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MicroBinfie Podcast, 76 What are the major challenges for getting AMR genomics into the clinic?

Released on March 3, 2022

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Major Challenges for Integrating AMR Genomics into Clinical Practice

The integration of antimicrobial resistance (AMR) genomics into clinical settings presents several significant challenges. These were the focus of a panel discussion during the 7th Microbial Bioinformatics Hackathon, organized in association with JPIAMR, PHA4GE, and CLIMB. The panel comprised experts from various institutions:

  • Mark Pallen from the Quadram Institute Bioscience, UK
  • Finlay Maguire from Dalhousie University, Canada
  • Anthony Underwood from the Centre for Genomic Pathogen Surveillance, UK
  • Clement Tsui from Weill Cornell Medicine, Qatar

The session was chaired by Andrew Page, with support from Lee Katz.

Key Challenges Discussed:

  1. Data Interpretation and Standardization:

    • Harmonizing diverse data types for consistent interpretation across different genomic platforms.
    • Developing standardized guidelines for interpreting genomic data in the clinical context.

  2. Infrastructure and Resources:

    • The need for robust computational infrastructure to handle large-scale genomic data.
    • Ensuring access to necessary resources and funding for ongoing genomic initiatives.

  3. Clinical Utility and Integration:

    • Demonstrating the direct clinical value and actionable nature of genomic data to healthcare providers.
    • Integrating genomic findings into existing clinical workflows and electronic health records.

  4. Regulatory and Ethical Concerns:

    • Addressing ethical issues related to patient data privacy and consent.
    • Navigating complex regulatory landscapes to ensure compliance and patient safety.

  5. Education and Training:

    • Providing sufficient training for healthcare professionals to interpret and utilize genomic data effectively.
    • Raising awareness and understanding of genomic technologies within the medical community.

  6. Collaborative Efforts:

    • Fostering international collaboration to share data, resources, and knowledge.
    • Encouraging partnerships between academic, governmental, and private sectors to advance genomic applications.

Addressing these challenges requires a concerted effort from the scientific community, healthcare providers, policy-makers, and other stakeholders to realize the full potential of AMR genomics in clinical practice.

Episode 76 transcript